This course presents the fundamentals of digital signal processing with emphasis on problems in biomedical research and clinical medicine. It covers basic principles and algorithms for processing both deterministic and random signals. Topics include data acquisition, imaging, filtering, coding, feature extraction, and modeling. The focus of the course is a series of MATLAB® lab exercises that provide practical experience with cardiologic data, speech signals, and medical images. Lectures cover signal processing topics relevant to the lab exercises, as well as background on the physiological signals processed in the labs.