Covers biological and bioengineering principles underlying the development and therapeutic use of recombinant proteins and immune cells. Special attention to monoclonal antibodies and engineered immune system cells as therapeutics; protein- and glyco- engineering to enhance protein function; protein pharmacology and delivery; nucleic acid- based biotherapeutics; generation of functional cells and tissues from embryonic stem cells and iPS cells; and immune cell-cancer cell interactions in cancer immunotherapy.