Course Syllabus

The Great Problems - Spring 2022 Syllabus

<The exact order of topics and required readings may change depending on guest speaker preferences>

Feb 1  

Feb 8    

Feb 15    

Feb 22   

Mar 1   

Mar 8 

Mar 15  

Mar 22  

Mar 29  

Apr 5    

Apr 12 

Apr 19

Apr 26    

May 3 

May 10

The present has no future

Nuclear devastation (Weber)

Biological catastrophe

<no class>   

Mistakes and defection

The planetary thermostat (Keith)

Coordinating preparedness

<no class>

Scientific norms around risk (Palmer)

Aligning AI systems (Christiano)

Rebuilding civilization

Improving well-being (Picard)

Catastrophic biology solutions

Final project presentations

Coordinating preparedness (Bright)

Feb 3       

Feb 10      

Feb 17  

Feb 24

Mar 3

Mar 10

Mar 17

Mar 24 

Mar 31 

Apr 7   

Apr 14

Apr 21

Apr 28   

May 5 

 

Storytelling and history

Stories and Great Powers

Timeline: transformative AI (Cotra)

Learning from history

Resilient food, water, power

Right idea, wrong PR

<topic of class choice>

<no class>

<topic of class choice>

Durable refuges (Karpur)

Abundant energy (White)

Climate or nuclear solutions

Solutions to AI

Final project presentations

 

Example project: engineering/solutions (reducing infectious disease transmission in buildings)

Example project: research/analysis (assessing the contribution of feeder rodents to animal suffering)

 

Syllabus (dates and assignments subject to change)

 

Feb 1 - The present has no future

At our current rate of economic growth, we’d be using every atom in the galaxy in less than 10,000 years… which is a problem because the Milky Way is more than 50,000 light-years across. In less that 150 years, we’ve gone from fountain pens to tweets, cavalry to ICBMs, and snake oil to CRISPR-mediated T cell therapy … yet somehow we imagine that the future will consist of people like us who are essentially still making all the decisions. If the present world cannot endure without catastrophe or radical transformation, then the future will be quite different from what most people expect. It might offer delight and fulfillment literally beyond our current capacity to imagine, a hellish dystopia, or an empty universe. If we prefer the first option, we’d better figure out how to live with what we will have.

 

Feb 3 - Storytelling and history

We’re creatures of the story. There is no human history without somebody capable of presenting a compelling narrative. And we can shape the future by deciding how to tell our story. How, then, can we describe the arc of human history in ways that will improve the future? What can we learn from it? How many people lived when, under what conditions? When and what were the turning points that changed history? Were they inventions, ideas, or wars? Which stories have changed the world? …for the better? And which have changed it for the worse?

Due:

 

Feb 8 - Nuclear game theory                    Guest: Andrew C. Weber

Leo Szilard, inventor of the chain reaction, warned that dropping the bomb on Japan in 1945 would accelerate an arms race that would make American cities vulnerable to foreign militaries for the first time in half a century. He was right. Nuclear weapons cannot be blocked, and can only be deterred through mutually assured destruction. Whether they kept the Cold War cold is debatable, but it was always touch and go. We came close to losing around half of humanity in 1983. What can we learn from our first experience with a technology capable of threatening civilization?

Due: 

Recommended: 

 

Feb 10 - Stories, cooperation, and Great Powers

Why do some narratives resonate in one place but not in others? How do different peoples view their history, and how does their perspective change how they interact with one another, and with technology? How can gatherings be structured to best create the most impactful outcomes? 

Due: 

 

Feb 15 - Biological catastrophe

COVID-19 was caused by a single, comparatively mild pandemic virus that wasn’t even engineered to cause harm.  Around thirty thousand people today could single-handedly assemble most viruses from synthetic DNA using cheap equipment. That number gets significantly larger every year as the price of computing power drops and the tools of genetic engineering grow. For years, scientists have tried to find viruses in nature that can harm us. Should they be doing that?  What would happen if they were to post a list of credible pandemic viruses found in nature? Or learn how to engineer more destructive ones? How can we best immunize civilization against catastrophic biology… and delay disaster until we have succeeded?

Due: 

 

Feb 17 - Timelines to transformative AI            Guest: Ajeya Cotra

We have already created systems with superhuman capacities. Soon AIs will be able to reliably accelerate the pace of science and technology development. That will likely return the world to a cycle of exponential growth and innovation that halted when we stopped having as many babies as we could feed, interrupting the sequential conversion of inventions into calories into inventors. The resumption of that cycle will mark the end of our current world. When will it happen, and how can we begin to prepare?

Due:

Recommended:

 

Feb 24 - Learning from history  

Who had the most positive impact on the world? Which inventions and ideas were critical? Conversely, which ideas and inventions were most harmful? Why? Was there ever a year in which discoveries caused more harm than good? Can we infer anything from that?

Due:

Recommended:

 

Mar 1 - Mistakes and defection

Do most catastrophic risks arise from accidents or deliberate actions? History suggests that our record on accidents is mixed, and could certainly be improved. But the real uncertainty concerns the number of people who would push a doomsday button, if given the opportunity. To date, only great powers have had that chance, and their actions are largely tempered by game theory. Should many more individuals gain that power, we may expect a different outcome.

Due:

 

Mar 3 - Resilient logistics: food, water, and power

There is an inherent tradeoff between efficiency and robustness. By definition, a maximally efficient system has no redundancy. Just-in-time manufacturing minimizes warehouse storage time and wasted materials, but is fragile to supply chain disruptions. How can we render our supply chains resilient when market forces work to render them fragile? Which are particularly at risk, and what can we do?

Due:

Recommended reading:

 

Mar 8 - The planetary thermostat                Guest: David Keith

Few people continue to doubt that climate change is real and that human activity is the major cause.  Many assume that warming of 2oC - a figure that only twenty years ago was considered catastrophic - is now unavoidable. That will dramatically increase water and food shortages in the poorest parts of the world and gradually submerge land occupied by a significant fraction of humanity. The long-term impacts, let alone the tail risks, will almost certainly make everything else more difficult. What can we do?

Due:

 

Mar 10 - Right idea, wrong PR

Some view technology as deterministic. But even if people will eventually adopt whatever is useful, multiple technologies may fill a need, in which case outside factors can decide which will be developed. To what extent does the success of a technology depend on its inventor? On a popularizer? A funder? What happens when a true and important idea is devised by the wrong person, or the wrong place? Or the opposite?

Due:

 

Mar 15 - Coordinating preparedness                 Guest: Rick Bright

COVID-19 gave us a reasonable snapshot of how well human civilization can be expected to respond in a global crisis. What can we learn from the last two years? Which institutions can we rely on? In which countries? Are there any patterns? How can we compensate for weaknesses and uncertainties?

Due:

 

 

Mar 17 - choice of topic to be determined by class interest

 

Mar 29 - Scientific norms & biorisk                 Guest: Megan Palmer

Many scientists, especially in biology, strongly believe in open research and data sharing. When the genome of the 1918 influenza virus and the report of its resurrection was published, the editor-in-chief of Science wrote that the journal would have published the genome sequence regardless of what the government advisory panel decided, and would only have refrained if threatened with jail. Can we reconcile the culture of openness with information hazards?

Due:

Recommended:

 

Mar 31 - choice of topic to be determined by class interest

 

Apr 5 - Aligning transformative AI                Guest: Paul Christiano

What happens when we create agents more capable than we are? After all, chimpanzees are nearly extinct and mostly reside in zoos. Ideally, we want anything with power to be not only as aligned with our interests as the average human, but much more so. Even given perfect alignment with human interests, machines with significantly superhuman competence will still upend the strategic gameboard, potentially creating incentives for people to act dangerously. To give just one example, superhuman competence in biology might create catastrophic threats that could reliably overcome our human-designed defenses. How can we both align transformative AI systems and prevent their superior capabilities from causing harm?

Due: 

Recommended:

 

Apr 7 - Building Refuges                    Guest: Ajay Karpur

If most of civilization falls, where might humanity survive and thrive? Can we deliberately build refuges that would help? Where should they be located, what will they need, and who should go there?

Due:

Relevant fiction:

 

Apr 12 - Rebuilding civilization

Given the non-trivial probability of civilization collapsing, it’s remarkable how little has been done to help the survivors rebuild. What do we most want to pass on to our successors? To their descendants? Can we learn anything from past civilizational collapses and recoveries? To what extent do the answers depend on the nature of the threat that ends the rest of us?

Due:

Recommended reading:

 

Apr 14 - Abundant energy                    Guest: Anne White

Some claim that recent technological advances were constrained by energy limitations. Computation, which is unquestionably the most transformative area of technology of the last fifty years, are noteworthy for requiring minimal energy. If we had access to unlimited clean energy, almost every material problem could, in principle, be solved.

Due:

Recommended:

 

Apr 19 - Improving well-being                Guest: Rosalind Picard

Nobody wants a future filled with misery. But suffering is incredibly widespread. At any given time, an estimated 20% of people experience some symptoms of mental illness. Many more are miserable. Suffering and mental illness make it hard to cooperate, so helping people lets them help more. To what degree are these problems biological, and how many are environmental? Do people care more about subjective happiness or fulfillment? What are the most effective treatments today? What can we invent to improve well-being? 

Due:

 

Apr 21 - Climate or nuclear solutions, or topic chosen by the class

 

Apr 26 - Biorisk solutions

 

Apr 28 - AGI solutions

 

May 3 - Final Project Presentations

 

May 5 - Final Project Presentations