Course Syllabus
Monday, Wednesday, and most Fridays 11a:12:30p
This course aims to develop deep quantitative understanding of basic forces of evolution, molecular evolution, genetic variations and their dynamics in populations, genetics of complex phenotypes, and genome-wide association studies. Application of these foundational concepts to cutting edge studies in epigenetics, gene regulation and chromatin; cancer genomics, and microbiomes. Modules consist of lectures, journal club discussions of high impact publications, and guest lectures that provide clinical correlates. Homework assignments and final projects aim to develop hands-on experience and understanding of genomic data from evolutionary principles.
Teaching Staff
Professor Leonid Mirny; leonid@mit.edu
Professor Tami Lieberman; tami@mit.edu
Office Hours: Tu 4-5p or as requested; E25-551b and Zoom simultaneous
TA Paul Torrillo; torrillo@mit.edu
Office Hours: M 2-3p; Zoom
Homework and Grading
- 3 Problem Sets (15% each; 45%)
- Participation in Paper Discussions (20%)
- Lead 1 discussion
- Leave comments on all papers by 9p day before class)
- Final project (~5 pages) (35%)
- Preliminary
- Oral
- Written
Textbooks
John H. Gillespie's Population Genetics: A Concise Guide
All documents are currently from 2022
All documents and deadlines currently uploaded are from 2022. We will be updating these shortly.
Course Summary:
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