Course Syllabus
Fundamentals of Science and Technology Public Policy
IAP 2026 Course 17.925 - MIT Science and Technology Policy Bootcamp
19th year of offering this course
draft: 11/16/25
Syllabus
Goal
Students will emerge from the course with a strong grasp of the fundamentals of innovation systems and the economic and technology development factors behind them, and with a clear framework to approach science and technology policymaking.
Logistics
Session: Monday January 26, 2025, to Friday January 30, 2025 (last week of MIT IAP 2026)
Instructor: William B. Bonvillian, bonvill@mit.edu
Lecturer, STS and Course 17; has been Director of MIT’s Washington Office, Senior Director, special projects, MIT Office of Open Learning and currently Senior Advisor, MIT Initiative for New Manufacturing – bio below
Office hours: the instructor will be available after classes to meet with students, and by email and zoom prior to and following the course
Classroom: 56-114
Class format: 7 classes, 5 lunchtime discussions, including an MIT faculty/researcher panel session
Course: either credit (3 points) or non-credit
TA: Grace Brown, gabrown@mit.edu
Schedule
Monday, January 26, 2026 (9:00am – 3:30pm)
Class 1: Economic Drivers Behind S&T Support
9:00am – 12:00pm
Lunchtime discussion 1: MIT Science Policy Initiative (SPI)
12:00pm – 1:00pm
Members of MIT’s Science Policy Initiative (SPI) student group discuss their program, including participating in Congressional Visits Day (CVD) and Executive Agency Visit Days (ExVD) (see summary of these SPI programs below)
Class 2: The Organizing Framework Behind U.S. Science Agencies
1:00pm – 3:30pm
Tuesday, January 27, 2026 (9:00am – 1:00pm) -
Class 3: Case Study – Barriers and Opportunities in Life Science Advance –The NIH Story
9:00am – 12:00pm
Lunchtime discussion 2: Career Paths in Science Policy
12:00pm – 1:00pm
Invited Speaker: Johanna Wolfson, who took this course and was a former leader of the MIT Science Policy Initiative group, who then went on to Fraunhofer TechBridge, the Dept. of Energy and now Prime Impact, where she is a general manager of its Azolla Ventures fund for energy startups, will discuss possible career paths for those interested in science and technology policy. Bio info here.
Wednesday, January 28, 2026 (9:00am – 3:30pm)
Class 4: The Organization of Innovation Systems at the Face-to-Face Level
9:00am – 12:00pm
Lunchtime discussion 3: The role of MIT in federal and state science policy
12:00pm – 1:00pm
Speaker: Dr. John Liu, PI of the MIT LEAP Group, Digital Learning Scientist, and Lecturer in Mechanical Engineering, who will discuss his work on developing the “Technologist” program for workforce education, which features online courses, VR simulations, and in-person labs to create a new career pathway between technicians and engineers for advanced manufacturing, https://openlearning.mit.edu/about/our-team/john-liu and please review: https://issues.org/technologist-advanced-manufacturing-workforce-liu-bonvillian/
Class 5: Case Study – Structuring for an Energy Technology Revolution
1:00pm – 3:30pm
Thursday, January 29, 2026 (9:00am – 1:00pm)
Class 6: Case Study – The Competitiveness Challenge in Advanced Manufacturing
9:00am – 12:00pm
Lunchtime discussion 4:
12:00pm – 1:00pm
Speaker: Prof. Maria Zuber, former MIT VP Research, former Chair of the National Science Board, and former co-chair of the President’s Council of Advisors on Science and Technology (PCAST), who will discuss MIT’s new science and technology initiative she is leading for MIT’s President - bio here: https://orgchart.mit.edu/leadership/presidential-advisor-science-and-technology-policy/biography
Friday, January 30, 2026 (9:00am – 1:30pm)
Class 7: Emerging Industrial Innovation Policies in the U.S.
9:00am – 12:00pm
Lunchtime Faculty Panel discussion:
12:15pm – 1:30pm
Speakers:
Prof. Chris Love is a Professor of Chemical Engineering, a member of the Koch Institute for Integrative Cancer Research at MIT, and an associate member of both the Broad and Ragon Institutes, and co-chair of the MIT Initiative for New Manufacturing. He will discuss biomanufacturing and its role in the bioeconomy. Bio at: https://ki.mit.edu/people/faculty/j-christopher-love
Prof. David Des Marais is a Professor in Civil and Environmental Engineering who studies plant and environment interaction including the physiological basis for plant responses to environmental cues. He will discuss biology and bioengineering aspects of agriculture within the bioeconomy. Bio at: https://cee.mit.edu/people_individual/david-l-des-marais/
Description
Careers of MIT scientists and engineers will be in significant part determined by public policy decisions made in Washington by the government, yet their access to information on how this system works – truly a “black box” – is limited. Meanwhile, we increasingly understand that science and technology-based innovation is deeply connected to society’s economic growth and its corresponding ability to generate societal wellbeing, as well as responses to health, climate and competitive challenges, so the public importance of science is growing. This course will examine the public policy behind, and the government’s role in, the science and technology-based innovation system. Emphasis will be placed on the U.S. S&T system, but international examples will be discussed. Given the challenges to future federal science support, this course will aim to equip those planning careers in and around science and technology, in public or private sectors, with the basic background for involvement in science policymaking.
Topics covered
The course will aim to cover the following topics:
- The drivers behind science and technology support: growth economics, direct and indirect innovation factors, innovation systems theory, the “valley of death” between R&D and public-private partnership models.
- The organizing framework behind U.S. science agencies, their missions and research organizational models, and the DARPA model as an alternative.
- The way innovation is organized when it’s face-to-face, including rulesets for great innovation teams.
- Mechanisms for technology transfer and commercialization, between university-industry-government.
- The innovation organization barriers and challenges to health science advance
- The energy technology challenge – how the science/tech innovation system needs to be organized to succeed in an existing and established complex economic sector.
- The competitiveness challenge in advanced manufacturing.
- Emerging industrial policies in the U.S. and the challenges of making them work.
Expectations of the Class
Time for student participation and discussions will be built into each class. Following topic presentations by the instructor, students, on a rotating basis, will lead the discussion in classes, as described below. Students are asked to commit to ATTEND ALL THE CLASSES, INCLUDING the session with the faculty on Friday, since the course is designed to be a cumulative series, with each class building on the prior classes.
Required Readings and the Discussion Leader System
Readings are available at the class online Canvas site – ALWAYS CHECK THIS FIRST; links to some readings or portions of readings are provided in the syllabus below. On the class Canvas site, all readings are available on the site under “Files” then “Readings;” for particular readings hover your cursor over the file name for each reading for details on the name of the particular reading.
To encourage discussion, we will use a discussion leader system in the course. Rotating through the class, students will be named discussion leaders for one of the readings discussed in the seven classes. Particular students will be asked to briefly summarize one reading for that class and lead class Q&A discussion on it. The discussion leaders will usually be organized on panels. Starting with the first class, these discussion leaders will be asked to carefully read over one of the readings that day and to briefly summarize the major points and, with prepared questions, to lead Q&A on their one article/reading, as listed under each class description below. The curriculum lists the particular readings for each class that individual students will lead discussion on, and where available, links to each. Discussion leader assignments will be announced before the course starts.
In addition, for each of the classes, all students in the course are asked to read one required reading, to develop background understanding in the issues being discussed in that class – these are noted under each class. Doing this will help your understanding a great deal.
Grading
This course is offered both for credit (for 3 points through the Political Science Department) and without credit.
For Credit Paper: Students taking the course for credit should alert the instructor and TA by January 15th before the course starts and will be expected to write a 4 page single-space paper on one of the two topics below:
- an innovation “Great Group” (see class 3), or
- a Technology Sector or a Technology Agency, Firm, or Institution.
Please choose a paper topic from one of these two areas. All the PowerPoint slides we used in class will be posted on the class Canvas site, and all the readings are on that site as well – please use them in developing your papers. Papers will be due on Monday, February 23th. Detailed directions will be provided on the paper in a memo posted on the class Canvas site under Assignments.
Follow-on opportunities
In addition, there are other follow-on events that the Science Policy Initiative (SPI) student organization puts together that class participants are encouraged to apply to and participate in:
Congressional Visits Day (CVD) in Spring 2026
The MIT Science Policy Initiative (SPI) will organize the Congressional Visit Days (CVD) in Washington, DC in Spring 2024 where participants will have the opportunity to interface with Congressional offices to advocate for and talk about science and technology issues. No prior experience is needed. Before the meetings, there will be training sessions through SPI and the MIT DC Office, and travel expenses and lodging will be provided.
Executive Visit Days (EVD) in Fall 2026
SPI will organize an agency visits program of meetings with officials from federal executive branch science agencies to learn first-hand from agency officials about the missions and structure of their organizations, and possible career paths. Meetings in the past have been with leading federal R&D agencies (like NSF, DARPA, DOE’s EERE, OSTP), with NGO’s (like the World Bank and the National Academies), and with think tanks (like Brookings and ITIF).
Other SPI Events – 2026 - SPI also organizes extensive activities around science and tech policy during the year you likely will be interested in.
Instructor
William B. Bonvillian is a Lecturer at the Massachusetts Institute of Technology, in MIT’s Science Technology and Society Department, teaching courses on innovation and on science and technology policy, including this course and an MITx online course. He is a Senior Advisor to MIT’s Initiative for New Manufacturing and has conducted research projects and programs on workforce education and technology topics. Previously, he was Director of MIT’s Washington, D.C. Office between 2006 and 2017, supporting MIT’s historic role on national science and technology policy. He was an advisor to MIT’s Production in the Innovation Economy study issued in 2013 and was an MIT representative to President Obama’s industry-university Advanced Manufacturing Partnership and for its reports of 2011 and 2014 setting new U.S. manufacturing policies. Prior to MIT, he served for over fifteen years as a senior policy advisor in the U.S. Senate working on innovation issues. Earlier, he was a Deputy Assistant Secretary in the U.S. Department of Transportation handling legislative issues.
His book, Pioneering Progress: American Science, Technology and Innovation Policy was published in October 2024 by MIT Press and analyzes these policies in depth. Workforce Education, a New Roadmap, with Prof. Sanjay E. Sarma of MIT, was released in 2021 by MIT Press and evaluates new models for workforce education. Advanced Manufacturing - The New American Innovation Policies, with Peter L. Singer, was published by MIT Press in 2018 and reviews strategies for production innovation to enable advanced manufacturing systems. His 2015 book Technological Innovation in Legacy Sectors, with Prof. Charles Weiss of Georgetown, was published by Oxford University Press and takes up the challenge of bringing innovation to complex, established “legacy” economic sectors that constitute most of the economy. Their book Structuring an Energy Technology Revolution, published by MIT Press in 2009, proposed new models for energy technology innovation. He was coeditor and contributor to the book The DARPA Model for Transformative Technologies from Open Book Publishers in 2020, which collected leading articles on DARPA. He has written over fifty articles and chapters on science and technology policy issues, including in Science, Issues in Science and Technology, Nature, Science and Public Policy, Innovations, Annals of Science and Technology Policy, Environment, American Interest and American Affairs.
He has lectured and given speeches before numerous organizations and universities on science, technology, and innovation questions. He has testified before the Congress’ House Science and Technology Committee, the Senate Commerce Committee, the House Defense Appropriations Subcommittee, and before the UK Parliament’s Committee on Science and Technology. He is on the National Academies of Sciences’ Board on Materials and Manufacturing and its standing committee for the Science Policy Forum, and has served on nine other Academies’ committees. He chaired the AAAS standing Committee on Science, Engineering and Public Policy (COSEPP) between 2017 and 2021, is on the GAO’s Polaris Council on Science and Technology, was on the Board of the Information Technology and Innovation Foundation and is a member of the Babbage Forum on Industrial Innovation Policy at Cambridge University. He has degrees from Columbia, Yale and Columbia Law School. He was the recipient of the IEEE Distinguished Public Service Award in 2007 and was elected a Fellow by the AAAS in 2011. (Webpage: https://www.bonvillian.org; bio info: https://en.wikipedia.org/wiki/William_Boone_Bonvillian)
Classes And Readings
Monday, January 26, 2026 (9:00am – 3:30pm)
Class 1: Economic Drivers Behind S&T Support
9:00am – 12:00pm
This class will focus on the drivers behind science and technology support since they are part of an economic system: growth economics, direct and indirect innovation factors, innovation systems theory, the “valley of death” between R&D, and public-private partnership models.
Class 1 will start by summarizing two classic works by Nobel Economics Prize winners Robert Solow and Paul Romer in economic growth theory, turn to a discussion of the innovation-related basis for growth in the 1990s with a reading from economist Dale Jorgensen, and note the emerging debate on the effect of the economics of globalization and the comparative efforts of other competitive nations. Two elements of direct or explicit innovation policy will be introduced: R&D support, (including the physical science R&D funding challenge) and the science and technology talent base, with international comparisons noted.
The class will also discuss a work by economist Richard Nelson with its concept of an innovation system, based on the capability of the actors in this system. It will have a summary of indirect (or implicit) elements in this system. These indirect elements include, on the governmental side, fiscal policy, tax policy, standards, technology transfer policies, trade policy, procurement, intellectual property, the legal system, regulation, antitrust, export controls, etc. On the private side, these include markets, management approaches including support for incremental verses radical innovation, accounting systems and information transparency, business models, and venture and angel capital, etc. The direct and indirect factors will be discussed as elements in an “innovation system,” building on the Nelson reading cited below. Particular “indirect elements” will be briefly noted, including the role of venture and angel capital. The lack of innovation metrics will be cited. The class will also discuss policy justifications for governmental verses private sector roles, including the debate over “industrial policy,” and the “market failure” and the “public value” (as pursued by science and technology mission agencies) justifications for a public role.
We will also discuss towards the end of the class the longstanding problem of the “valley of death”, i.e., of moving technology from the research stage through the development stage, the extent private sector finance is prepared to undertake technology development risk, and discuss the pipeline (linear) model verses dynamic model for research and development.
Students will take away from this class key foundation elements in sci/tech public policy: 1) a review of the applicable aspects of growth economics theory, 2) the concept of innovation systems and the actors and players behind them, 3) a framework for looking at an innovation system of direct and indirect factors, and 4) a grasp of one of the deepest problems in innovation, the “valley of death” between research and development.
Other readings for individual students to lead class discussions
Robert M. Solow (Prof. of Economics, MIT), Growth Theory, An Exposition (Oxford Univ. Press, New York, Oxford, 2nd edition 2000), pp. ix-xxvi (Nobel Prize Lecture, Dec. 8, 1987, http://nobelprize.org/nobel_prizes/economics/laureates/1987/solow-lecture.html
[note: skip the econometrics, focus only on underlying substantive points]
Paul Romer (Prof. of Economics, NYU) Endogenous Technological Change, Journal of Political Economy, vol. 98, n. 5(1990), pp. 71-102, https://web.stanford.edu/~klenow/Romer_1990.pdf [note: focus only on underlying substantive themes, you are not required to review the econometrics material]
Dale Jorgenson (Prof. of Economics, Harvard), U.S. Economic Growth in the Information Age, Issues in Science and Technology (NAS publication, Wash., D.C., Fall 2001 issue) https://issues.org/jorgenson/[role of IT drivers in ‘90’s growth]
Steven Milunovich and John M.A. Roy, The Next Small Thing, An Introduction to Nanotechnology (Merrill Lynch, Comment 2001), https://www.slideshare.net/tseitlin/intro-to-nanotechnology-merrill-lynch [example of investor evaluation of technology investment option]
Lewis Branscomb (Harvard, Kennedy School emeritus) and Phillip Auerswald (George Mason Univ., Pub. Pol.) Between Invention and Innovation, An Analysis of Funding for Early-State Technology Development (NIST GCR 02-841) (Nov. 2002), Part I –Understanding Early Stage Technology Development, pp. 27-57, https://www.nist.gov/system/files/documents/2017/05/09/gcr02-841.pdf
[evaluation of “Valley of Death” problem]
Optional reading that covers these issues: William B. Bonvillian, Pioneering Progress, American Science, Technology and Innovation Policy (MIT Press 2024), chapters 1 and 2 -- book available free on “Open Access” at: https://direct.mit.edu/books/oa-monograph/5865/Pioneering-ProgressAmerican-Science-Technology-and
***
Lunchtime discussion: MIT Science Policy Initiative
12:00pm – 1:00pm
Members of MIT’s Science Policy Initiative (SPI) student group discuss their program, including participating in Congressional Visits Day (CVD) and Executive Agency Visit Days (ExVD) (see summary of these SPI programs below)
Class 2: The Organizing Framework Behind U.S. Science Agencies
1:00pm – 3:30pm – Monday
This class will make the argument that Sci/Tech organization is a third direct innovation factor and examine the organizational framework behind the mix of U.S. science agencies, their missions and research organizational models. It will examine the basic science agencies and contrast it with the DARPA model as an organizational alternative. Thus, this class will look at the U.S. innovation system at the institutional level, emphasizing the organization of federal science support.
The class will start with a review of key organizational developments in federal science, technology, and health support, focusing on the organizational models for the missions of those science-support organizations, against a backdrop of the underlying political/economic ideologies of the U.S. system, using Prof. David Hart’s framework. Potential strengths of government-supported R&D (selection neutrality and long-range focus) as well as concerns (peer review tending toward incremental progress not breakthroughs and isolation from application connections) will be discussed. The pre-WWII organization will be briefly noted, then the transformation of science during WWII under Vannevar Bush and Alfred Loomis, and the creation of the National Science Foundation and other basic research entities after the war.
The review will focus on the overall organizational structure and as part of that note the following developments:
- Alfred Loomis and the FFRDC (Federally-Funded Research and Development Center) model at MIT’s Rad Lab – the contract R&D entity outside the government
- Vannevar Bush and the “Endless Frontier” – in the wake of WW2’s focus on applied research, Bush’s proposal for government science support focused on fundamental research
- Origins of NSF, based on federal support of outside, university-based fundamental research, under Vannevar Bush’s “pipeline” model
- Dean Donald Stokes’ critique of that model in Pasteur’s Quadrant
- The military role in U.S. innovation support as reviewed by Vernon Ruttan
- Origins of DARPA based on focused revolutionary research in an industry-university collaboration model. There will be a discussion focus on the DARPA organizational model as an organizing alternative to the Bush basic research model. DARPA’s role in innovation on both the institutional and personal levels of innovation will be reviewed.
Students will take away from this class the foundational concepts that led to the way the U.S. organizes its science and technology mission agencies and review alternative models that led to more connected science systems.
Other readings for individual students to lead class discussions
David Hart, Forged Consensus (Princeton Univ. Press, 1998) pp. 17-29 (portions available here: https://www.google.com/books/edition/Forged_Consensus/EqUuvUdrs_MC?hl=en&gbpv=1&printsec=frontcover) [political forces behind the history of pre-WWII U.S. science policy]
Vannevar Bush, Science: The Endless Frontier (Government Printing Office,
Wash., D.C. 1945) p. 1-27 (FDR and Bush letters, Summary, Introduction, major goals) (on nsf.gov website -https://www.nsf.gov/about/history/vbush1945.htm
[Bush’s proposal for federal support for basic research through NSF]
Donald E. Stokes (Princeton), Pasteur’s Quadrant, Basic Science and Technological Innovation (Brookings Univ. Press 1997) pp. 1-25, 45-57, 58-89 - portions found at: https://courses.cs.washington.edu/courses/cse510/16wi/readings/stokes_pasteurs_quadrant.pdf [breakdown from the basic and applied science distinctions]
Vernon W. Ruttan, Is War Necessary for Economic Growth? Military Procurement and Technology Development (Oxford Univ. Press 2006), Chapts. 2 (pp. 21-31) (interchangeable parts) and 5 (pp. 91-111) (computing),) (optional – Chapt. 6 (internet) (pp. 115-129) (portions available here: https://www.google.com/books/edition/Is_War_Necessary_for_Economic_Growth/Eopn-pYI1tsC?hl=en&gbpv=1&printsec=frontcover) [profound defense role in U.S. information technology innovation process]
William B. Bonvillian “The Connected Science Model for Innovation – The DARPA Model,” in The DARPA Model for Transformative Technologies (Bonvillian, VanAtta and Windham, eds.) (Open Book Publishers 2020) pp. 77-113, pdf at: https://www.openbookpublishers.com/product/1079 [the DARPA “right-left” breakthrough innovation model]
(Not a required reading but the instructor will discuss it, see: Jennet Conant, Tuxedo Park (Simon and Shuster 2002) (biography of Alfred L. Loomis founder of MIT’s Rad Lab) pp. 178-289 (Chapters 9-12) (some portionsavailable here: https://www.google.com/books/edition/Tuxedo_Park/QQTZAAAAQBAJ?hl=en&gbpv=1&printsec=frontcover (Links to an external site.))[MIT’s Rad Lab emerges in WWII as model for federally funded but not controlled R&D centers]
Optional reading that covers these issues: William B. Bonvillian, Pioneering Progress, American Science, Technology and Innovation Policy (MIT Press 2024), chapters 3, 4 and 6 -- book available free on “Open Access” at: https://direct.mit.edu/books/oa-monograph/5865/Pioneering-ProgressAmerican-Science-Technology-and
Tuesday, January 27, 2026 (9:00am – 1:00pm)
Class 3: Case Study – Barriers and Opportunities in Life Science Advance –The NIH Story
9:00am – 12:00pm
Class 3 will take the ideas discussed in the two prior classes and apply them to the innovation organization of the health science sector. It will note the organizational origins of NIH in the fundamental research model and discuss the implications of that model for the role NIH plays in the biomedical innovation system. Key topics, including NIH's role in training life science researchers for university and industry, the origins of the human genome project, around a new computational science model, the rise of the biotech sector, the role of biotech firms in the development stage, and the power of the patent system in life sciences, will be discussed. NIH problems in pursuing cross-disciplinary, translational, and physical and engineering science-based research, with organizational stovepipes, and in attacking niche, developing world, and small disease population diseases will also be reviewed. Proposals from the National Academy of Medicine (formerly the Institute of Medicine) and others for NIH reorganization will be discussed. Problems in developing therapies for infectious disease and with developing new approaches to drug validation and approval will be discussed through reports from the Infectious Diseases Society and FDA. The “blockbuster” product development model in the health sector will be discussed.
Class 3 will also review new ways to better transition health technology advances into medicines for treatments and cures. The class will include a review of an MIT white paper on better integrating life science with engineering and physical science (“convergence”) as a promising new R&D model. It will also discuss Operation Warp Speed, which made Covid-19 vaccines available to the public in record time in 2020-21 during the pandemic and the organizational mechanisms that allowed rapid development.
Students will take from this class an understanding of the barriers to health science advances at NIH and FDA, and review the new “convergence” model developing at MIT that could affect innovation in this sector.
Other readings for individual students to lead class discussions
National Institute of Medicine (NAS – National Academy of Medicine), Enhancing the Vitality of the National Institutes of Health: Organizational Changes to Meet New Challenges (National Academies Press, Wash., D.C. 2003), pp.1- 101, https://www.nap.edu/catalog/10779/enhancing-the-vitality-of-the-national-institutes-of-health-organizational [innovation organizational issues at NIH]
Robert Cook-Deegan, Does NIH Need a DARPA? Issues in Science and Technology (National Academy of Sciences publication, Winter 1996), https://issues.org/cookde/ [argues the NIH needs a DARPA approach within its centers and institutes]
Infectious Diseases Society of America, Report on Bad Bugs, No Drugs – As Antibiotic Discovery Stagnates A Public Health Crisis Brews (July 2004), pp. 3-28, https://www.idsociety.org/globalassets/idsa/policy--advocacy/current_topics_and_issues/antimicrobial_resistance/10x20/statements/070104-as-antibiotic-discovery-stagnates-a-public-health-crisis-brews.pdf
[Infectious diseases fall outside the “blockbuster model” creating a health crisis]
FDA, Innovation/Stagnation - Challenge and Opportunity on the Critical Path to New Medical Products (March 2004), http://wayback.archive-it.org/7993/20180125032208/https://www.fda.gov/ScienceResearch/SpecialTopics/CriticalPathInitiative/CriticalPathOpportunitiesReports/ucm077262.htm [FDA faces a crisis in slow review process for drugs and devices and lacks the R&D funding to address it]
MIT, Convergence: The Future of Health (led by MIT Profs. Phillip Sharp, Susan Hockfield and Tyler Jacks) (MIT White Paper – June 2016), https://www.aplu.org/wp-content/uploads/convergence_futureofHealth.pdf [explores the alternative “convergence” research model for health science advance, linking biology with engineering, physical and information sciences, as opposed to the NIH biology-only model]
(Not a required reading, but for interested students, see, PCAST, Propelling Innovation in Drug Discovery, Development and Evaluation (Sept. 2012), Exec. Summary, pp. v-xiv, https://www.broadinstitute.org/files/sections/about/PCAST/2012%20pcast-fda.pdf [overall problems with the health science innovation system])
Optional reading that covers these issues: William B. Bonvillian, Pioneering Progress, American Science, Technology and Innovation Policy (MIT Press 2024), chapter 8 -- book available free on “Open Access” at: https://direct.mit.edu/books/oa-monograph/5865/Pioneering-ProgressAmerican-Science-Technology-and
***
Lunchtime discussion: Career Paths in Science Policy
12:00pm – 1:00pm
Invited: Johanna Wolfson who took this course and was a former leader of the MIT Science Policy Initiative group, who then went on to Fraunhofer TechBridge, the Department of Energy, and Prime Impact, where she is general partner for its Azolla Ventures energy tech investment fund. She will discuss career opportunities in Science and Tech Policy.
Wednesday, January 28, 2026 (9:00am – 3:30pm)
Class 4: The Organization of Innovation Systems at the Face-to-Face Level
9:00am – 12:00pm
Class 4 will be more informal and student-led by discussion leaders (see below). We will note that although innovation systems function at the institutional level in the public and private sectors, as discussed in Class 2 (and was the basis for the case study in Class 3) they also must function at the personal, face-to-face level. The class will first look at the psychology of the invention process itself (using Rosen’s book on the industrial revolution), then review a series of breakthrough innovations and look at the R&D teams that assembled them, discussing the organizational rule sets that appear to be common to these great innovation groups. The focus groups include Edison’s “Invention Factory”, J. Robert Oppenheimer and Los Alamos, Bardeen, Brattain, and Shockley developing the transistor at Bell Labs, Grace Hopper and the development of computer programming languages, Katherine Johnson and the “hidden figures” at NASA, Lockheed’s “Skunkworks,” Herbert Boyer and Robert Swanson founding the first biotech Genetech, Craig Venter and the genome project, and Robert Taylor and Xerox PARC. The session will close with a review of lessons from a “great group” at DEC, where the founding innovation culture failed as the firm transitioned to a major corporation.
Directions for Discussion Leaders: Discussion leaders should read about their assigned innovation "Great Group," prepare no more than four PowerPoint slides about the group for presentation to the class, present the groups' accomplishments and organization, summarize four or five rules from the Bennis and Biederman ruleset (see this reading below) that most apply to their group, and develop one or two rules from looking at their group of their own. They will brief the class on their group, using their slides.
Students will take from this discussion class an understanding of how people- and team- driven, as opposed to institution-driven, the innovation stage is, and of the rulesets that appear to influence innovation success.
Other readings for individual students to lead class discussions
William Rosen, The Most Powerful Idea in the World, A Story of Steam, Industry and Invention (Random House, N.Y. 2010) pp. 35-39, 115, portions of the book are available in: https://books.google.com/books?id=-TStyXy7F6oC&printsec=frontcover&source=gbs_ge_summary_r&cad=0#v=onepage&q&f=false [the role of the tactile, vision, and social networks in invention]
Sir Harold Evans, They Made America – From the Steam Engine to the Search Engine: Two centuries of American Innovators (Sloan Foundation project; Little Brown & Co. 2004), pp.152-171, portions of the book are here (see “read sample”), https://www.amazon.com/They-Made-America-Centuries-Innovators/dp/0316277665?asin=0316277665&revisionId=&format=4&depth=1
[Thomas Edison’s “Invention Factory”],
Kai Bird and Martin J. Sherwin, American Prometheus, J. Robert Oppenheimer, (Alfred A. Knopf 2005) pp. 205-228, 255-259, 268-285, 293-297, portions available at, see “preview”: https://books.google.com/books?id=jfSn2RJZI9EC&printsec=frontcover&source=gbs_ge_summary_r&cad=0#v=onepage&q&f=false[Oppenheimer and the Manhattan Project at Los Alamos]
Lillian Hoddeson and Vicki Daitch, True Genius – The Life and Science of John Bardeen (Joseph Henry Press of the National Academy 2002) pp. 115-154, portions of the book available here, https://play.google.com/books/reader?id=AFwnsrMG_-AC&hl=en&pg=GBS.PP1
[John Bardeen, Walter Brattain, and William Shockley and the development of the transistor at Bell Labs]
Kathleen Broome Williams, Grace Hopper, Admiral of the Cyber Sea (Naval Institute Press 2004, pp. 68-98 (Ch. 3), portions here, https://www.google.com/books/edition/Grace_Hopper/KKmiw-_2gYIC?q=&gbpv=1#f=false and see also, Grace Hopper Wikipedia entry, https://en.wikipedia.org/wiki/Grace_Hopper[Grace Hopper, developer of the compiler and natural language computer programming and COBOL programming language]
Katherine Johnson, Reaching for the Moon (Atheneum Books 2019 – autobiography) 131-237, book excerpthere: https://www.space.com/reaching-for-the-moon-katherine-johnson-excerpt.html [this short book will need to be obtained from the library; see generally, Margot Shetterly, Hidden Figures: The American Dream and the Black Women Mathematicians Who Helped Win the Space Race (2016), information here: ttps://www.amazon.com/-/es/Margot-Lee-Shetterly/dp/0062363603 and https://en.wikipedia.org/wiki/Katherine_Johnson [Katherine Johnson, research mathematician and part of the “hidden figures” group at NASA]
Ben Rich, Skunk Works (Little Brown 1995), excerpts from Chapter 1 available at https://books.google.com/books?id=oL4bHPIt7XIC [Lockheed’s Skunk Works, a model for how a corporation can organize and undertake recurring innovation]
Sir Harold Evans, They Made America – From the Steam Engine to the Search Engine: Two centuries of American Innovators (Sloan Foundation project; Little Brown & Co. 2004), pp.420-431on Boyer and Swanson (see link above for portions) [Boyer and Swanson found Genetech and start biotech]
Warren Bennis (Prof., USC, Marshall Sch. of Business) and Patricia Ward Biederman, Organizing Genius, The Secrets of Creative Collaborative (Basic Books 1997) pp. 63-86 [the Xerox Parc group]
James Shreeve, The Genome War (2004), chapters 5-7, 9 portions of the book here, https://www.google.com/books/edition/The_Genome_War/GERcyqzOP9MC?hl=en&gbpv=1&printsec=frontcover and read interview of the author on Craig Ventor at: https://www.penguinrandomhouse.com/books/166441/the-genome-war-by-james-shreeve/9780345433749/[Craig Venter and his group and the genome sequencing effort]
Edgar Schein, DEC Is Dead, Long Live DEC – Lessons on Innovation, Technology and the Business Gene (BK Berrett-Kohler Publishers, San Francisco 2004) pp. 123-169, portions of the book available here, https://www.econstor.eu/bitstream/10419/290434/1/9781040005163.pdf [how a founding great group at DECwas unable to manage the transition to an enduring major corporation]
Optional reading that covers these issues: William B. Bonvillian, Pioneering Progress, American Science, Technology and Innovation Policy (MIT Press 2024), chapter 5 -- book available free on “Open Access” at: https://direct.mit.edu/books/oa-monograph/5865/Pioneering-ProgressAmerican-Science-Technology-and
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Lunchtime discussion:
12:00pm – 1:00pm
Speaker: Dr. John Liu, PI of the MIT LEAP Group, Digital Learning Scientist, and Lecturer in Mechanical Engineering, who will discuss his work on developing the “Technologist” program for workforce education, which features online courses, VR simulations, and in-person labs to create a new career pathway between technicians and engineers for advanced manufacturing - bio: https://openlearning.mit.edu/about/our-team/john-liu,
And please review in advance: https://issues.org/technologist-advanced-manufacturing-workforce-liu-bonvillian/
Class 5: Case Study – Structuring for an Energy Technology Revolution
1:00pm – 3:30pm - Wednesday
Class 5 will review the challenges to the energy innovation system, including both institutional organizational challenges and underlying economic challenges, affecting energy technology advance. Given the political collapse in 2011 of “cap and trade” proposals for pricing carbon, the class will look at alternative pathways by which an energy transformation could evolve.
The instructor will review the innovation policy elements that could be considered as part of a major federal program to stimulate innovation in energy technology, which has now been evolving. Given the central role of energy in the economy and the variety of new technologies needed, this program needs to go beyond research and development to include all aspects of the innovation process. It would also need to be as technology neutral as possible, consistent with the need for measures to overcome obstacles specific to particular technologies. Ideally, the instructor will note, such a technology supply-side program should be accompanied by market demand policies that ensure market entry for new technologies. However, given interests opposing and threatened by such measures, political support for such demand-side policies in Congress and the executive branch appears many years away. The political barriers to a technology supply-side strategy, on the other hand, are not as high.
Given the depth of the need for new energy technology, a supply side program arguably will be needed even if demand measures are adopted. Numerous authoritative publications have called for an expansion of energy research and development as a complement to demand-side measures. However, the specific mechanisms by which the development, deployment and diffusion of these technologies might be facilitated by government action have been left largely unstudied. A hard look at these specific mechanisms will be a major topic in the class. The R&D elements evolving at the Department of Energy, such as ARPA-E, will be reviewed, along with the need for creating energy technology demonstrations, testbeds, and initial markets. Alternative drivers and policies for energy technology advance will be explored overall.
Given the powerful and increasing importance of energy innovation in climate and security contexts, this class will provide students with a close look at the systemic challenges now faced by the energy innovation system and draw on lessons from prior classes for possible organizational solutions.
Other readings for individual students to lead class discussions
Stephen W. Pacala and Robert H. Socolow, Stabilization Wedges: Solving the Climate Problem for the Next 50 Years with Current Technologies”, Science, Vol 305 (Aug. 13, 2004), https://fire.pppl.gov/energy_socolow_081304.pdf
[“wedges” theory for implementing energy technology advances]
William B. Bonvillian and Richard VanAtta, ARPA-E and DARPA, Applying the DARPA Model to Energy Innovation, Journal of Technology Transfer (Oct. 2011), Sections 1, 3, and 4(B) (pages 1-4, -31, 38-41), portions available at: https://www.researchgate.net/publication/226579961_ARPA-E_and_DARPA_Applying_the_DARPA_model_to_energy_innovation
William B. Bonvillian, Addressing the Scaleup Challenge for “Hard” Technology Startups, Annals of Science and Technology, v.1, no.1 (March 2017) (section 4), https://www.nowpublishers.com/article/Details/ASTP-001[the challenge of scaleup for startups attempting complex technologies that must be manufactured including for energy]
David M. Hart, William B. Bonvillian, Nathaniel Austin, Energy Storage for the Grid: Policy Options for Sustaining Innovation (MIT Energy initiative Working Paper April 2018), http://energy.mit.edu/publication/energy-storage-for-the-grid [state-led innovation initiatives, “dominant technology” challenges and “stranded innovation” energy technologies]
Accessing Trump Administration policies: 3 short pieces -
- Evan Helper and Chico Harlan, The real winners of Trump’s attack on clear energy aren’t American, W. Post, Oct. 12, 2025, https://www.washingtonpost.com/climate-environment/2025/10/09/solar-clean-energy-trump-china/;
- Carlos Garcia Soto, Reversing climate progress; consequences and solutions in the wake of US policy rollbacks, Nature npj Climate Action, July 2, 2025, https://www.nature.com/articles/s44168-025-00247-0
- David Uberti, Ed Ballard, and Brian Spegele, The US is Forfeiting the Clean Energy Race to China, Wall Street Journal, Sept. 21, 2025, https://www.wsj.com/economy/global/the-u-s-is-forfeiting-the-clean-energy-race-to-china-e822ab57
Optional reading that covers these issues: William B. Bonvillian, Pioneering Progress, American Science, Technology and Innovation Policy (MIT Press 2024), chapter 10 -- book available free on “Open Access” at: https://direct.mit.edu/books/oa-monograph/5865/Pioneering-ProgressAmerican-Science-Technology-and
Thursday, January 29, 2026 (9:00am – 1:00pm)
Class 6: Case Study – The Competitiveness Challenge in Advanced Manufacturing
9:00am – 12:00pm
Class 6 will focus on the oncoming competitiveness challenge in advanced technologies for production, looking closely at U.S. manufacturing, the translator for most physical science related advances into societal economic gain and a major "scalable" factor for economic growth.
Class 6 will note the nature of the competitiveness debate of the 80s and early 90s, which focused on the manufacturing sector, particularly on process efficiency and quality. The role of manufacturing in the U.S. economy, including its ties to the innovation system, will be discussed, including its declining share of that economy. The nature of the international competition in manufacturing and the strategies of other international competitors, both in the 80s and now, including in advanced manufacturing sectors, will be reviewed. Approaches in Germany, Japan, Korea, and, currently, China will be noted. As background reading, students will read Paul Samuelson’s noted 2004 article on free trade theory in a period of competitive advantage in innovation. Prof. Suzanne Berger’s milestone work on the distributed model for U.S. manufacturing organization will be reviewed. The 2012 and 2014 reports from the President's industry-university Advanced Manufacturing Partnership, and the resulting Advanced Manufacturing Institute program, will be discussed by the instructor, providing lessons on structural economic issues in the U.S. production system. Work by the instructor summarizing U.S. manufacturing challenges and the role of advanced manufacturing technologies will be reviewed and discussed. In this regard, the “disruptive technologies” approach to innovation will be noted, as well as corresponding possible approaches for manufacturing process technology productivity breakthroughs. The discussion will close with a discussion of the “future of work” given entry of new automation technologies.
A major rationale for federal R&D support has become its role in promoting U.S. competitiveness, yet a declining U.S. manufacturing sector appears increasingly less able to translate innovation gains into product production economic gains. Students will obtain from this class a summary of the current advanced manufacturing debate in the U.S. in manufacturing sectors.
Other readings for individual students to lead class discussions
Paul A. Samuelson (Prof. of Economics, MIT), Where Ricardo and Mill Rebut and Confirm Arguments of Mainstream Economists Supporting Globalization, Journal of Economic Perspectives, Vol. 18, No. 3 (Summer 2004), pp. 135-137, 144-145,
http://pubs.aeaweb.org/doi/pdfplus/10.1257/0895330042162403
[economic fundamentals of trade and offshore outsourcing; skip the econometrics and formulas]
Suzanne Berger (MIT), How We Compete: What Companies Around the World Are Doing to Make it in Today's Global Economy (Doubleday/Currency 2005)(chapter 11 (pp. 251-277)), information not content here: https://books.google.co.uk/books/about/How_We_Compete.html?id=Va21AAAAIAAJ&redir_esc=y [the distributed model for manufacturing firms]
Jonas Nahm and Edward Steinfeld, Scale-Up Nation: Chinese Specialization in Innovative Manufacturing (MIT working paper March 12, 2012), http://www.hbs.edu/faculty/conferences/2013-bgie/Documents/SteinfeldNahm.pdf [China’s “scale-up” manufacturing capability]
Noah Smith, Why Every Country Needs to Master the Electric Stack, Noahopinion, September 2, 2025, https://www.noahpinion.blog/p/why-every-country-needs-to-master?utm_source=post-email-title&publication_id=35345&post_id=174317837&utm_campaign=email-post-title&isFreemail=false&r=9ajwd&triedRedirect=true&utm_medium=email
Optional reading that covers these issues: William B. Bonvillian, Pioneering Progress, American Science, Technology and Innovation Policy (MIT Press 2024), chapter 9 -- book available free on “Open Access” at: https://direct.mit.edu/books/oa-monograph/5865/Pioneering-ProgressAmerican-Science-Technology-and
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Lunchtime discussion –
12:00pm – 1:00pm
Speaker: Prof. Maria Zuber, former MIT VP Research, former Chair of the National Science Board, and former co-chair of the President’s Council of Advisors on Science and Technology (PCAST), who will discuss MIT’s new science and technology initiative she is leading for MIT’s President - bio: https://orgchart.mit.edu/leadership/presidential-advisor-science-and-technology-policy/biography
Friday, January 30, 2026 (9:00am – 1:30pm)
Class 7: Emerging Industrial Innovation Policies in the U.S.
9:00am – 12:00pm
Despite longstanding opposition from mainstream economists to industrial policy, in the period of 2020-2021 the United States, confronted by advanced technology competition from China, the demands of climate change, and the need to respond to a global pandemic, adopted a series of major industrial policy programs. Although the U.S. Defense Department has long practiced industrial policy approaches, and the U.S. has followed industrial economic policies in its agriculture, transportation, electric power and healthcare sectors, there have been new programs focused on promoting technology innovation, so can be labeled “industrial innovation policy.” The large scale of these efforts amounted to a new step for the U.S. in non-defense sectors. However, some but not all of these efforts are now being pulled back.
Although the definition of industrial policy is debated, with some arguing it should serve social needs verses specific technology advances, this study adopts a more straightforward definition. Industrial innovation policy involves governmental intervention in one or more of the post-research innovation stages, from development to prototyping to production, to further technology innovation. The class will review these issues, including examples of new U.S. industrial innovation policies adopted between 2020 and 2022: Operation Warp Speed for coronavirus pandemic vaccines; the CHIPS Act to restore U.S. semiconductor leadership); the Inflation Reduction Act, with its impetus for implementation of new energy technologies, which has now been cut back; and the CHIPS and Science Act, with its support for applied development of critical technologies and regional innovation. These adopt an industrial innovation policy approach and launch a series of models for it. A remaining gap in U.S. industrial policy efforts is support for technology scale-up; a comparison is made with China’s more extensive mechanisms for scale-up. In addition, a case study of U.S. vs. China electric vehicle industrial policies is discussed, as well as a case study on semiconductors. The class will close with a discussion of the need for the U.S. to adopt a new kind of infrastructure and accompanying operational mechanisms in order to make its new industrial innovation policies work, drawn from the required reading.
Other readings for individual students to lead class discussions
David Adler, Guiding Finance: China’s Strategy for Funding Advanced Manufacturing, American Affairs, Summer 2022, https://americanaffairsjournal.org/2022/05/guiding-finance-chinas-strategy-for-funding-advanced-manufacturing/
Gerard DiPippo, Ilaria Mazzocco, Scott Kennedy and Matthew Goodman, Red Ink: Estimating Chinese Industrial Policy Spending in Comparative Perspective, CSIS, May 23, 2022, https://www.csis.org/analysis/red-ink-estimating-chinese-industrial-policy-spending-comparative-perspective
Zeyi Yang, How did China come to dominate the world of electric vehicles? MIT Technology Review, Feb. 21, 2023, https://www.technologyreview.com/2023/02/21/1068880/how-did-china-dominate-electric-cars-policy/
Kenneth Flamm and William B. Bonvillian, Part 1: How Intel’s Innovation Problem Became a National Security Crisis, American Affairs, v.9, n.1, Spring 2025, https://americanaffairsjournal.org/2025/02/how-intels-innovation-problem-became-a-national-security-crisis/ and Flamm and Bonvillian, Part 2: Solving America’s Chip Manufacturing Crisis, American Affairs, v.9, n. 2, Summer 2025, https://americanaffairsjournal.org/2025/05/solving-americas-chip-manufacturing-crisis/
David Autor and Gordon Hanson, We Warned About the First China Shock. The Next One Will be Worse, New York Times (opinion), July 14, 2025, https://www.nytimes.com/2025/07/14/opinion/china-shock-economy-manufacturing.html?partner=slack&smid=sl-share
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Lunchtime Faculty Panel Discussion:
12:15pm – 1:30pm
Speakers: Prof. Chris Love is a Professor of Chemical Engineering, a member of the Koch Institute for Integrative Cancer Research at MIT, and an associate member of both the Broad and Ragon Institutes, and co-chair of the MIT Initiative for New Manufacturing. He will discuss biomanufacturing and its role in the emerging bioeconomy. Bio at: https://ki.mit.edu/people/faculty/j-christopher-love
Prof. David Des Marais is a Professor in Civil and Environmental Engineering who studies plant and environment interaction including the physiological basis for plant responses to environmental cues. He will discuss biology and bioengineering aspects of agriculture within the bioeconomy. Bio at: https://cee.mit.edu/people_individual/david-l-des-marais/